Regular aerobic exercise increased VEGF levels in both soleus and gastrocnemius muscles correlated with hippocampal learning and VEGF levels

Physical exercise improves learning and memory abilities by increasing the levels of several growth factors in hippocampus. One factor, vascular endothelial factor (VEGF), is primarily produced muscles not only increases periphery during but can also cross blood-brain barrier. The aim this study to investigate effects regular aerobic chronic on different types muscle fibers relationships between learning/memory induced-VEGF. Following a one-week adaptation period, male rats underwent treadmill training at speed 8 m/min for 30 min daily, 3 days week 6 weeks. Memory functions were evaluated using Morris water maze. VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) measured type 1 2 VEGF Exercise positively affected both increased fiber types. Muscle correlate with hippocampal levels. reduced SOD MDA fibers, whereas GPx decreased fibers. Our findings suggest that elevates diminishes oxidative stress Exercise-induced appear be associated positive effect function accompanied an increase Further research needed elucidate exact mechanism which type-specific mediates neurogenesis angiogenesis.